Quinolone-Resistant Neisseria gonorrhoeae; The Beginning of the End? Report of Quinolone-Resistant Isolates and Surveillance in the Southwestern United States, 1989 to 1997

Background: Fluoroquinolones are one of the most widely used treatments for gonorrhoeae. Changes in the susceptibility of Neisseria gonorrhoeae to these agents may threaten their use. Goal of this study: To report several resistant strains (>1 mcg/ml) isolated in the western United States and to...

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Bibliographic Details
Published in:Sexually transmitted diseases 1998-11, Vol.25 (10), p.522-526
Main Authors: EHRET, JOSEPHINE M., JUDSON, FRANKLYN N.
Format: Article
Language:English
Subjects:
Adult
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Drug Resistance, Microbial
Fluoroquinolones
Gonorrhea - epidemiology
Gonorrhea - microbiology
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Microbial Sensitivity Tests
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - isolation & purification
Pharmacology. Drug treatments
Southwestern United States - epidemiology
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Summary:Background: Fluoroquinolones are one of the most widely used treatments for gonorrhoeae. Changes in the susceptibility of Neisseria gonorrhoeae to these agents may threaten their use. Goal of this study: To report several resistant strains (>1 mcg/ml) isolated in the western United States and to evaluate the prevalence of strains with reduced susceptibility (ofloxacin 0.25 mcg/ml, ciprofloxacin 0.06 mcg/ml). Study Design: The microbiology and epidemiology of three resistant strains were characterized and 12,761 other strains were evaluated for fluoroquinolone susceptibility as part of the Gonococcal Isolate Surveillance Project of the Centers for Disease Control and Prevention. Results: Fluoroquinolone-resistant strains may appear sporadically. The prevalence of isolates with reduced susceptibility to fluoroquinolones remains low in the Southwest region of the United States. Conclusions: Continued active surveillance is needed to detect and control the spread of quinolone-resistant Neisseria gonorrhoeae.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-199811000-00005