Conditioned Effects of Kindling Three Different Sites in the Hippocampal Complex of the Rat

Rats received kindling stimulations to the perirhinal cortex (PRh), ventral hippocampus (VH), or dorsal hippocampus (DH) in 1 environment and an equivalent number of sham stimulations in a 2nd environment. The PRh-kindled rats displayed rapid kindling and a swift emergence of conditioned interictal...

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Bibliographic Details
Published in:Behavioral neuroscience 2005-12, Vol.119 (6), p.1572-1579
Main Authors: Barnes, Steven J, Hua, Josephine M, Pinel, John P. J, Wig, Gagan S, Takahashi, Aki
Format: Article
Language:English
Subjects:
Animal
Animal behavior
Animals
Behavior, Animal
Biological and medical sciences
Brain
Brain Mapping
Conditioning
Conditioning (Psychology) - physiology
Defensiveness
Electric Stimulation - methods
Electrodes, Implanted
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - physiology
Kindling
Kindling, Neurologic - physiology
Learning. Memory
Male
Naphthalenes
Neurology
Oxepins
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Random Allocation
Rats
Rats, Long-Evans
Rodents
Time Factors
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Summary:Rats received kindling stimulations to the perirhinal cortex (PRh), ventral hippocampus (VH), or dorsal hippocampus (DH) in 1 environment and an equivalent number of sham stimulations in a 2nd environment. The PRh-kindled rats displayed rapid kindling and a swift emergence of conditioned interictal defensiveness. In contrast, the VH- and DH-kindled rats displayed much slower kindling and slow or no conditioning, respectively. No effects of conditioning on the convulsions, comparable with those associated with amygdala kindling, were observed. These results establish the generality of some of the previously reported kindling-related conditioned effects, confirm the site specificity of some of these effects, and suggest that the convulsions, rather than the stimulations, function as the unconditioned stimuli for the conditioning of interictal behavior.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.119.6.1572