New HLA DRB1 and DQB1 Haplotypes in a Pedigree of Familial Graves' Disease in Japan

The present study demonstrated genetic analysis of human leukocyte antigen (HLA) in a familial Graves' disease linked to autoimmune mechanism. The proband was a 17 year-old female. At 15 years, Graves' disease was diagnosed with serum TSH was

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Bibliographic Details
Published in:Endocrine Journal 2007, Vol.54(5), pp.721-725
Main Authors: SASAKI, Masami, YUZAWA, Miho, SAITO, Tomoyuki, IKOMA, Aki, TAMEMOTO, Hiroyuki, KAWAKAMI, Masanobu, ISHIKAWA, San-e
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aged
Childhood-onset
Familial onset
Family
Female
Graves Disease - genetics
Graves' disease
Haplotypes
HLA
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Hyperthyroidism
Japan
Male
Membrane Glycoproteins - genetics
Middle Aged
Pedigree
Thyroid Function Tests
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Description
Summary:The present study demonstrated genetic analysis of human leukocyte antigen (HLA) in a familial Graves' disease linked to autoimmune mechanism. The proband was a 17 year-old female. At 15 years, Graves' disease was diagnosed with serum TSH was
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K06-215