Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1

Heat-shock proteins (HSPs) or antibodies against them may contribute to glaucomatous optic neuropathy. We investigated the associations of HSP70-1 polymorphisms with open-angle glaucoma (OAG) in a Japanese population. In 241 normal Japanese controls and 501 Japanese OAG patients, including 211 with...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2007-11, Vol.51 (6), p.417-423
Main Authors: Tosaka, Karin, Mashima, Yukihiko, Funayama, Tomoyo, Ohtake, Yuichiro, Kimura, Itaru
Format: Article
Language:English
Subjects:
Aged
Female
Genotype
Glaucoma
Glaucoma, Open-Angle - diagnosis
Glaucoma, Open-Angle - genetics
Gonioscopy
HSP72 Heat-Shock Proteins - genetics
Humans
Intraocular Pressure
Male
Middle Aged
Optic Nerve Diseases - diagnosis
Optic Nerve Diseases - genetics
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide - genetics
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Summary:Heat-shock proteins (HSPs) or antibodies against them may contribute to glaucomatous optic neuropathy. We investigated the associations of HSP70-1 polymorphisms with open-angle glaucoma (OAG) in a Japanese population. In 241 normal Japanese controls and 501 Japanese OAG patients, including 211 with primary open-angle glaucoma (POAG) and 290 with normal-tension glaucoma (NTG), two single-nucleotide polymorphisms, A-110C and G+190C, of HSP70-1 were identified by using an Invader assay and polymerase chain reaction-restriction fragment length polymorphism, respectively. Genotype distributions were compared between controls and OAG patients. Age at diagnosis, untreated maximum intraocular pressure, and visual field defects at diagnosis were examined for associations with the polymorphisms. Distribution of the A-110C genotype (AA versus AC+CC) differed significantly between controls and OAG patients (P = 0.007), POAG patients (P = 0.007), or NTG patients (P = 0.032). The genotype distribution of the G+190C polymorphism did not differ significantly between the controls and any patient group. No significant differences in the clinical characteristics of the patients were detected between genotype-defined groups by logistic regression analysis. The A-110C polymorphism of HSP70-1 may be associated with OAG pathogenesis in Japanese patients.
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-007-0475-9