Augmentation as a treatment complication of restless legs syndrome: Concept and management

Augmentation constitutes the main complication of long‐term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster...

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Bibliographic Details
Published in:Movement disorders 2007, Vol.22 (S18), p.S476-S484
Main Authors: García-Borreguero, Diego, Allen, Richard P., Benes, Heike, Earley, Christopher, Happe, Svenja, Högl, Birgit, Kohnen, Ralf, Paulus, Walter, Rye, David, Winkelmann, Juliane
Format: Article
Language:English
Subjects:
augmentation
diagnosis
Disease Progression
Dopamine Agents - adverse effects
Dopamine Agents - therapeutic use
dopaminergic treatment
Humans
pathophysiology
restless legs syndrome
Restless Legs Syndrome - drug therapy
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Summary:Augmentation constitutes the main complication of long‐term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003. These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition. © 2007 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.21610