Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death

We have recently reported that maternal dietary imbalance during pregnancy and lactation can reduce the lifespan of offspring. Rats that were growth restricted in utero by maternal protein restriction and underwent rapid weight gain when suckled by control fed dams died earlier than animals whose mo...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2007-11, Vol.128 (11), p.681-687
Main Authors: Shelley, Piran, Tarry-Adkins, Jane, Martin-Gronert, Malgorzata, Poston, Lucilla, Heales, Simon, Clark, John, Ozanne, Susan, McConnell, Josie
Format: Article
Language:English
Subjects:
Aging
Animals
Animals, Newborn
Biological and medical sciences
Coenzymes - deficiency
CoQ
Development. Metamorphosis. Moult. Ageing
Developmental programming
Diet, Protein-Restricted
Disease Models, Animal
DNA Damage
Electron Transport Chain Complex Proteins - metabolism
Female
Fetal Growth Retardation - genetics
Fetal Growth Retardation - metabolism
Fetal Growth Retardation - physiopathology
Fundamental and applied biological sciences. Psychology
Kidney - enzymology
Kidney - metabolism
Lactation
Longevity
Male
Mitochondria
Mitochondria - metabolism
Pregnancy
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena
Rats
Rats, Wistar
ROS
Telomere - metabolism
Telomeres
Time Factors
Ubiquinone - analogs & derivatives
Ubiquinone - deficiency
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight Gain
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Summary:We have recently reported that maternal dietary imbalance during pregnancy and lactation can reduce the lifespan of offspring. Rats that were growth restricted in utero by maternal protein restriction and underwent rapid weight gain when suckled by control fed dams died earlier than animals whose mothers were fed a control diet throughout pregnancy and lactation. We demonstrate here that mitochondrial abnormalities and DNA damage occur in the kidney of offspring who die prematurely. We have established by direct measurement and by in vitro supplementation that mitochondrial abnormalities occur because of a functional deficit of the mitochondrial cofactor coenzyme Q9 (CoQ9). These data provide molecular insight into the association between maternal nutrition and determination of offspring lifespan, and identify, a potential dietary intervention to prevent detrimental consequences of imbalanced maternal nutrition.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2007.10.002