Feasibility study of lactate imaging of head and neck tumors

A proton spectroscopic imaging sequence was used to investigate the feasibility of lactate imaging in head and neck tumors. The sequence employs a two‐shot lactate editing method with inversion recovery for additional lipid suppression, and a restricted field of view to suppress motion artifacts. Va...

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Bibliographic Details
Published in:NMR in biomedicine 1998-11, Vol.11 (7), p.360-369
Main Authors: Adalsteinsson, E., Spielman, D. M., Pauly, J. M., Terris, D. J., Sommer, G., Macovski, A.
Format: Article
Language:English
Subjects:
Adult
Aged
Feasibility Studies
Female
Head and Neck Neoplasms - chemistry
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - surgery
head and neck tumors
Humans
in vivo lactate
lactic acid
Lactic Acid - analysis
Magnetic Resonance Spectroscopy
Male
Middle Aged
spectroscopic imaging
squamous cell carcinoma
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Summary:A proton spectroscopic imaging sequence was used to investigate the feasibility of lactate imaging in head and neck tumors. The sequence employs a two‐shot lactate editing method with inversion recovery for additional lipid suppression, and a restricted field of view to suppress motion artifacts. Variations in acquisition parameters and two different receive coils were investigated on twelve patients. Elevated lactate was detected in three patients, no lactate was observed in seven patients, and two studies were inconclusive because of severe motion or inhomogeneity artifacts. Best results were obtained with an anterior/posterior neck coil at a 288 ms echo time (TE). © 1998 John Wiley & Sons, Ltd.
ISSN:0952-3480
1099-1492
DOI:10.1002/(SICI)1099-1492(1998110)11:7<360::AID-NBM518>3.0.CO;2-P