Detection of the sentinel lymph node in breast cancer

Introduction Introduction: Axillary lymph node status for lymphatic staging in breast cancer is the best prognostic indicator and guides systemic treatment. Sentinel lymph node (SLN) biopsy is a novel, minimally invasive technique for lymphatic staging proven to improve quality of life. The accurate...

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Bibliographic Details
Published in:British medical bulletin 2007-01, Vol.84 (1), p.117-131
Main Authors: Somasundaram, Santosh K., Chicken, Dennis W., Keshtgar, Mohammed R. S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
General aspects
Gynecology. Andrology. Obstetrics
Humans
Lymph Nodes - pathology
Mammary gland diseases
Medical sciences
Neoplasm Staging - methods
NEW START
Radiopharmaceuticals
sentinel lymph node
Sentinel Lymph Node Biopsy - methods
sentinel node imaging
Tumors
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Summary:Introduction Introduction: Axillary lymph node status for lymphatic staging in breast cancer is the best prognostic indicator and guides systemic treatment. Sentinel lymph node (SLN) biopsy is a novel, minimally invasive technique for lymphatic staging proven to improve quality of life. The accurate detection of the SLN is paramount for the success of the procedure. Methods Relevant literature was reviewed with regards to the different dyes and techniques used for the detection of SLN in breast cancer. Results Highest identification rates and lowest false negative rates are achieved by using the combined blue dye and radiocolloid technique with pre-operative imaging using a gamma camera. There is a well-recognized learning curve to successfully perform SLN biopsy. Conclusions The concept of SLN has been well validated and is the standard of care in early breast cancer. A multidisciplinary approach and structured training is the key to the successful introduction of the technique.
ISSN:0007-1420
1471-8391
DOI:10.1093/bmb/ldm032