Increased formation of distinct F2 isoprostanes in hypercholesterolemia

F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF2alpha-III and iPF2alpha-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprost...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-12, Vol.98 (25), p.2822-2828
Main Authors: REILLY, M. P, PRATICO, D, DELANTY, N, DIMINNO, G, TREMOLI, E, RADER, D, KAPOOR, S, ROKACH, J, LAWSON, J, FITZGERALD, G. A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arteriosclerosis - metabolism
Biological and medical sciences
Biomarkers - urine
Child
Child, Preschool
Cholesterol - blood
Dinoprost - analogs & derivatives
Dinoprost - urine
Disorders of blood lipids. Hyperlipoproteinemia
F2-Isoprostanes
Female
Humans
Hyperlipoproteinemia Type II - metabolism
Male
Medical sciences
Metabolic diseases
Prospective Studies
Tropical medicine
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Summary:F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF2alpha-III and iPF2alpha-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF2alpha-III (pmol/mmol creatinine) was elevated (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.98.25.2822