Influence of the management of cervical carcinoma on the activity of catalase and glutathione peroxidase in erythrocytes

The aim of the study was to determine the effect of different types of management on the activity of catalase (CAT) and glutathione peroxidase (GPx) in women with cervical carcinoma. The patients were divided into three groups according to the mode of treatment. Patients from the first group were tr...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2007, Vol.28 (6), p.461-463
Main Authors: Woźniak, B, Mila-Kierzenkowska, C, Kedziora-Kornatowska, K, Drewa, T, Drewa, G, Woźniak, A, Krzyzyńska-Malinowska, E, Makarewicz, R
Format: Article
Language:English
Subjects:
Catalase - blood
Erythrocytes - enzymology
Female
Glutathione Peroxidase - blood
Humans
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - enzymology
Uterine Cervical Neoplasms - radiotherapy
Uterine Cervical Neoplasms - surgery
Uterine Cervical Neoplasms - therapy
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Summary:The aim of the study was to determine the effect of different types of management on the activity of catalase (CAT) and glutathione peroxidase (GPx) in women with cervical carcinoma. The patients were divided into three groups according to the mode of treatment. Patients from the first group were treated brachytherapy prior to surgery. The second group received teletherapy before brachytherapy and additionally chemotherapy. The third group was treated with teletherapy after brachytherapy sessions. CAT activity was higher while GPx activity was lower before and during therapy in all groups as compared to controls. Six months after the end of therapy, the activity of studied enzymes reached the values characteristic of healthy women. No significant differences in enzyme activity among the three groups were revealed. Normalization of CAT and GPx activity may prove the efficacy of applied therapy in cervical cancer patients, however enzyme activity recovery was not dependent on treatment mode.
ISSN:0392-2936