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Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities
The present study retrospectively examines the correlation between the outcome of patients with locally advanced esophageal squamous cell carcinoma (LAEC) after multimodal treatment (radiochemotherapy +/- surgery) and the expression of apoptosis-regulating proteins in pretherapeutic biopsies. Thirty...
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| Published in: | Clinical cancer research 1998-12, Vol.4 (12), p.2991-2997 |
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| container_title | Clinical cancer research |
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| creator | SARBIA, M STAHL, M FINK, U WILLERS, R SEEBER, S GABBERT, H. E |
| description | The present study retrospectively examines the correlation between the outcome of patients with locally advanced esophageal
squamous cell carcinoma (LAEC) after multimodal treatment (radiochemotherapy +/- surgery) and the expression of apoptosis-regulating
proteins in pretherapeutic biopsies. Thirty-eight patients with LAEC who took part in a prospective multicentric trial received
radiochemotherapy, optionally followed by surgery. Pretreatment tumor biopsies were immunohistochemically investigated for
expression of p53, Bcl-2, Bax (bcl-2-associated X protein), and Bcl-X(L) (bcl-2-related X protein). The overall expression
of p53, Bcl-2, Bax, and Bcl-X(L) was 52.6, 57.9, 100, and 97.4% respectively. Tumors without p53 expression and tumors with
weak Bcl-X(L) expression showed response to chemotherapy more frequently (55.6 and 52.6%, respectively) than tumors positive
for p53 expression and tumors with strong Bcl-X(L) expression (30.0 and 31.6%, respectively); however, these differences did
not attain statistical significance. No correlations were found between the expression of Bcl-2 and Bax and the response to
chemotherapy. In patients treated by radiochemotherapy and surgery, p53-negative tumors showed a significantly better outcome
than p53-positive tumors (mean survival, 31.1 months versus 11.3 months; P = 0.0378). Additionally, a more favorable outcome
was observed in tumors positive for Bcl-2 (not significant), whereas no differences in survival were observed in relation
to the expression of Bax or Bcl-X(L). No differences in survival were observed in patients treated by radiochemotherapy without
subsequent resection therapy in relation to the expression of apoptosis-regulating proteins. Immunohistochemical examination
of pretherapeutic tumor biopsies for expression of apoptosis-regulating proteins may help to identify patients with LAEC who
may benefit from multimodal treatment and those who may not. |
| format | article |
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squamous cell carcinoma (LAEC) after multimodal treatment (radiochemotherapy +/- surgery) and the expression of apoptosis-regulating
proteins in pretherapeutic biopsies. Thirty-eight patients with LAEC who took part in a prospective multicentric trial received
radiochemotherapy, optionally followed by surgery. Pretreatment tumor biopsies were immunohistochemically investigated for
expression of p53, Bcl-2, Bax (bcl-2-associated X protein), and Bcl-X(L) (bcl-2-related X protein). The overall expression
of p53, Bcl-2, Bax, and Bcl-X(L) was 52.6, 57.9, 100, and 97.4% respectively. Tumors without p53 expression and tumors with
weak Bcl-X(L) expression showed response to chemotherapy more frequently (55.6 and 52.6%, respectively) than tumors positive
for p53 expression and tumors with strong Bcl-X(L) expression (30.0 and 31.6%, respectively); however, these differences did
not attain statistical significance. No correlations were found between the expression of Bcl-2 and Bax and the response to
chemotherapy. In patients treated by radiochemotherapy and surgery, p53-negative tumors showed a significantly better outcome
than p53-positive tumors (mean survival, 31.1 months versus 11.3 months; P = 0.0378). Additionally, a more favorable outcome
was observed in tumors positive for Bcl-2 (not significant), whereas no differences in survival were observed in relation
to the expression of Bax or Bcl-X(L). No differences in survival were observed in patients treated by radiochemotherapy without
subsequent resection therapy in relation to the expression of apoptosis-regulating proteins. Immunohistochemical examination
of pretherapeutic tumor biopsies for expression of apoptosis-regulating proteins may help to identify patients with LAEC who
may benefit from multimodal treatment and those who may not.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9865911</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Antineoplastic agents ; bcl-2-Associated X Protein ; bcl-X Protein ; Biological and medical sciences ; Biomarkers, Tumor - biosynthesis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Combined Modality Therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Epithelium - metabolism ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophagus - metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prognosis ; Proto-Oncogene Proteins - biosynthesis ; Proto-Oncogene Proteins c-bcl-2 - biosynthesis ; Retrospective Studies ; Survival Rate ; Tumor Suppressor Protein p53 - biosynthesis</subject><ispartof>Clinical cancer research, 1998-12, Vol.4 (12), p.2991-2997</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1662956$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9865911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SARBIA, M</creatorcontrib><creatorcontrib>STAHL, M</creatorcontrib><creatorcontrib>FINK, U</creatorcontrib><creatorcontrib>WILLERS, R</creatorcontrib><creatorcontrib>SEEBER, S</creatorcontrib><creatorcontrib>GABBERT, H. E</creatorcontrib><title>Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>The present study retrospectively examines the correlation between the outcome of patients with locally advanced esophageal
squamous cell carcinoma (LAEC) after multimodal treatment (radiochemotherapy +/- surgery) and the expression of apoptosis-regulating
proteins in pretherapeutic biopsies. Thirty-eight patients with LAEC who took part in a prospective multicentric trial received
radiochemotherapy, optionally followed by surgery. Pretreatment tumor biopsies were immunohistochemically investigated for
expression of p53, Bcl-2, Bax (bcl-2-associated X protein), and Bcl-X(L) (bcl-2-related X protein). The overall expression
of p53, Bcl-2, Bax, and Bcl-X(L) was 52.6, 57.9, 100, and 97.4% respectively. Tumors without p53 expression and tumors with
weak Bcl-X(L) expression showed response to chemotherapy more frequently (55.6 and 52.6%, respectively) than tumors positive
for p53 expression and tumors with strong Bcl-X(L) expression (30.0 and 31.6%, respectively); however, these differences did
not attain statistical significance. No correlations were found between the expression of Bcl-2 and Bax and the response to
chemotherapy. In patients treated by radiochemotherapy and surgery, p53-negative tumors showed a significantly better outcome
than p53-positive tumors (mean survival, 31.1 months versus 11.3 months; P = 0.0378). Additionally, a more favorable outcome
was observed in tumors positive for Bcl-2 (not significant), whereas no differences in survival were observed in relation
to the expression of Bax or Bcl-X(L). No differences in survival were observed in patients treated by radiochemotherapy without
subsequent resection therapy in relation to the expression of apoptosis-regulating proteins. Immunohistochemical examination
of pretherapeutic tumor biopsies for expression of apoptosis-regulating proteins may help to identify patients with LAEC who
may benefit from multimodal treatment and those who may not.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>bcl-2-Associated X Protein</subject><subject>bcl-X Protein</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Epithelium - metabolism</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagus - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNo9kM1LxDAQxYsofv8JQg4iXgpJ2qTJUcQvWPCi5zKbTLeRtqlJii74xxvZxdM85v1m4L2D4pQJ0ZQVl-Iwa9qoktYVPynOYvyglNWM1sfFsVZSaMZOi5-H7zlgjM5PxHcEZj8nH10sA26WAZKbNmQOPqGbIoHJEr8k40f8gzH6uYcNwkAMTAYDmfMBTimSFBASWrLekkyv3ZR16jHAvCWjtzC4DMaL4qiDIeLlfp4X748Pb_fP5er16eX-blX2XKpUNopxjtBYptYIJu-Usp1WXNDaoOUcOm5qW1Ne2a6ztOFCVEphbaUwQlfVeXGz-5uTfC4YUzu6aHAYYEK_xFZqqqWsVAav9uCyHtG2c3AjhG27ryv713sfooGhCzm2i_8Yk5JrITN2u8N6t-m_XMB2108uGiGYvq1bxluuNat-AYzXhSY</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>SARBIA, M</creator><creator>STAHL, M</creator><creator>FINK, U</creator><creator>WILLERS, R</creator><creator>SEEBER, S</creator><creator>GABBERT, H. E</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities</title><author>SARBIA, M ; STAHL, M ; FINK, U ; WILLERS, R ; SEEBER, S ; GABBERT, H. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-78122ea7d18beac26888df982504ced22af2c4d4023dffd07255388e4d65c5933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>bcl-2-Associated X Protein</topic><topic>bcl-X Protein</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Combined Modality Therapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Epithelium - metabolism</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagus - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins - biosynthesis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SARBIA, M</creatorcontrib><creatorcontrib>STAHL, M</creatorcontrib><creatorcontrib>FINK, U</creatorcontrib><creatorcontrib>WILLERS, R</creatorcontrib><creatorcontrib>SEEBER, S</creatorcontrib><creatorcontrib>GABBERT, H. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SARBIA, M</au><au>STAHL, M</au><au>FINK, U</au><au>WILLERS, R</au><au>SEEBER, S</au><au>GABBERT, H. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>4</volume><issue>12</issue><spage>2991</spage><epage>2997</epage><pages>2991-2997</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>The present study retrospectively examines the correlation between the outcome of patients with locally advanced esophageal
squamous cell carcinoma (LAEC) after multimodal treatment (radiochemotherapy +/- surgery) and the expression of apoptosis-regulating
proteins in pretherapeutic biopsies. Thirty-eight patients with LAEC who took part in a prospective multicentric trial received
radiochemotherapy, optionally followed by surgery. Pretreatment tumor biopsies were immunohistochemically investigated for
expression of p53, Bcl-2, Bax (bcl-2-associated X protein), and Bcl-X(L) (bcl-2-related X protein). The overall expression
of p53, Bcl-2, Bax, and Bcl-X(L) was 52.6, 57.9, 100, and 97.4% respectively. Tumors without p53 expression and tumors with
weak Bcl-X(L) expression showed response to chemotherapy more frequently (55.6 and 52.6%, respectively) than tumors positive
for p53 expression and tumors with strong Bcl-X(L) expression (30.0 and 31.6%, respectively); however, these differences did
not attain statistical significance. No correlations were found between the expression of Bcl-2 and Bax and the response to
chemotherapy. In patients treated by radiochemotherapy and surgery, p53-negative tumors showed a significantly better outcome
than p53-positive tumors (mean survival, 31.1 months versus 11.3 months; P = 0.0378). Additionally, a more favorable outcome
was observed in tumors positive for Bcl-2 (not significant), whereas no differences in survival were observed in relation
to the expression of Bax or Bcl-X(L). No differences in survival were observed in patients treated by radiochemotherapy without
subsequent resection therapy in relation to the expression of apoptosis-regulating proteins. Immunohistochemical examination
of pretherapeutic tumor biopsies for expression of apoptosis-regulating proteins may help to identify patients with LAEC who
may benefit from multimodal treatment and those who may not.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9865911</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Clinical cancer research, 1998-12, Vol.4 (12), p.2991-2997 |
| issn | 1078-0432 1557-3265 |
| language | eng |
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| source | Freely Accessible Science Journals |
| subjects | Adult Aged Antineoplastic agents bcl-2-Associated X Protein bcl-X Protein Biological and medical sciences Biomarkers, Tumor - biosynthesis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Epithelium - metabolism Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagus - metabolism Female Humans Immunohistochemistry Male Medical sciences Middle Aged Pharmacology. Drug treatments Prognosis Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-bcl-2 - biosynthesis Retrospective Studies Survival Rate Tumor Suppressor Protein p53 - biosynthesis |
| title | Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities |
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