Validation of left ventricular volume measurements by gated SPECT 99mTc-labeled sestamibi imaging

Previous studies have shown that gated single photon emission computed tomography (SPECT) technetium 99-labeled sestamibi imaging provides accurate and reproducible measurement of left ventricular (LV) ejection fraction (EF), wall motion, and thickening. This study examined the reliability of gated...

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Bibliographic Details
Published in:Journal of nuclear cardiology 1998-11, Vol.5 (6), p.574-578
Main Authors: Iskandrian, A E, Germano, G, VanDecker, W, Ogilby, J D, Wolf, N, Mintz, R, Berman, D S
Format: Article
Language:English
Subjects:
Cardiac Output
Cardiac Volume
Cardiology
Female
Gated Blood-Pool Imaging
Heart attacks
Humans
Male
Medical imaging
Middle Aged
Radiopharmaceuticals
Reproducibility of Results
Risk assessment
Standard deviation
Stroke Volume
Technetium Tc 99m Sestamibi
Thermodilution
Tomography, Emission-Computed, Single-Photon
Ventriculography, First-Pass
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Summary:Previous studies have shown that gated single photon emission computed tomography (SPECT) technetium 99-labeled sestamibi imaging provides accurate and reproducible measurement of left ventricular (LV) ejection fraction (EF), wall motion, and thickening. This study examined the reliability of gated SPECT sestamibi imaging in measuring LV end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV). Gated SPECT measurements were compared with an independent nongeometric method based on thermodilution SV and first-pass radionuclide angiographic EF (using a multicrystal gamma camera). Twenty-four patients aged 58+/-11 years underwent cardiac catheterization and coronary angiography for evaluation of chest pain syndromes. None had primary valvular disease, intracardiac shunts, or atrial fibrillation. The correlation between the two methods were as follows: EDV: r = 0.89, P
ISSN:1071-3581
1532-6551
DOI:10.1016/s1071-3581(98)90111-8