Lack of association between the G‐2548A polymorphism of the leptin gene and psoriasis in a Turkish population

• Published in: International journal of dermatology 2007-12, Vol.46 (12), p.1271-1274
• Main Authors: Kara, Nurten, Aydin, Fatma, Senturk, Nilgün, Gunes, Sezgin, Canturk, M. Tayyar, Bagci, Hasan, Bek, Yüksel, Turanli, Ahmet Yasar
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; Dermatology; Female; Gene Expression Regulation; Gene Frequency; Genotype; Humans; Leptin - genetics; Male; Medical sciences; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Psoriasis - genetics; Psoriasis. Parapsoriasis. Lichen; Turkey
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/j.1365-4632.2007.03324.x

Background   Psoriasis is a multifactorial disease in which genetic and inflammatory factors play important roles. Leptin is classified as a cytokine and plays an important role in the regulation of the T‐helper response. A common polymorphism in the promoter of the human leptin gene (G‐2548A) may have a role in the pathogenesis of psoriasis. Aim  To investigate the association between psoriasis and leptin gene polymorphism (G‐2548A). Methods  The study involved 109 patients with psoriasis and 125 healthy controls. Analyses of G‐2548A polymorphism of the leptin gene were made by the polymerase chain reaction‐restriction fragment length polymorphism technique. The genotypes (GG, GA, and AA of leptin gene G‐2548A) and alleles (G and A) were scored and the frequencies were estimated. The frequencies of alleles and genotypes in patients and controls were compared. The relationship between leptin gene polymorphism and the clinical features of the patients was analyzed. Results  Both genotype [odds ratio (OR), 0.921; 95% confidence interval (CI), 0.501–1.694; P = 0.792] and allele (OR, 0.864; 95% CI, 0.600–1.242; P = 0.429) frequencies were not significantly different between patient and control groups. In addition, there was no significant association between genotype and allele frequencies and the clinical characteristics of psoriasis. Conclusion  In this case–control study, no evidence of association between the G‐2548A variant of the leptin gene and psoriasis was found.