The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence

The salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in this regard are a privileged site of virus immune evasion. The murine cytomegalovirus (MCMV) model has provided insight into the immunological environment of the SG and the unqiue virus–host relationship of t...

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Bibliographic Details
Published in:Medical microbiology and immunology 2008-06, Vol.197 (2), p.205-213
Main Authors: Campbell, Ann E., Cavanaugh, Victoria J., Slater, Jacquelyn S.
Format: Article
Language:English
Subjects:
Apoptosis
Biomedicine
Body fluids
CD4 antigen
CD8 antigen
Cytomegalovirus
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - virology
Effector cells
Immune evasion
Immune response (cell-mediated)
Immunology
Interleukin 10
Interleukin-10 - immunology
Lymphocytes T
Medical Microbiology
Microbiology
Murine cytomegalovirus
Muromegalovirus - growth & development
Muromegalovirus - immunology
Review
Salivary gland
Salivary Glands - immunology
Salivary Glands - virology
Signal transduction
T-Lymphocytes - immunology
Virology
Viruses
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Summary:The salivary glands (SG) provide a haven for persistent cytomegalovirus replication, and in this regard are a privileged site of virus immune evasion. The murine cytomegalovirus (MCMV) model has provided insight into the immunological environment of the SG and the unqiue virus–host relationship of this organ. In response to MCMV infection, a robust T cell-mediated immune response is elicited, comprised predominantly of CD8+ T cells that phenotypically and functionally appear activated. However, they fail to clear virus by an unknown evasion mechanism that is independent of inhibitory NKG2A- or Programmed Death 1-mediated signaling. Virus is eventually eliminated from the SG by effector CD4+ T cells expressing antiviral cytokines. However, this mechanism is severely dampened by high levels of the immunosuppressive cytokine IL-10, selectively expressed by SG CD4+ T cells.
ISSN:0300-8584
1432-1831
DOI:10.1007/s00430-008-0077-2