Up-regulation of glial cell line-derived neurotrophic factor (GDNF) expression in regenerating muscle fibers in neuromuscular diseases

Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert a target-derived trophic factor for motor neurons. Immunohistochemical analyses revealed that expression of GDNF in regeneration muscle fibers was up-regulated in polymyositis (PM) and Duchenne type muscular dystrophy (DMD)....

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Bibliographic Details
Published in:Neuroscience letters 1998-12, Vol.257 (3), p.165-167
Main Authors: Suzuki, Hidenori, Hase, Asako, Yoon Kim, Bong, Miyata, Yuhei, Ikuya Nonaka, Arahata, Kiichi, Akazawa a, Chihiro
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Diseases of striated muscles. Neuromuscular diseases
Duchenne type muscular dystrophy
Glial Cell Line-Derived Neurotrophic Factor
Human
Humans
Immunohistochemistry
Medical sciences
Muscle Fibers, Skeletal - metabolism
Muscle Fibers, Skeletal - physiology
Muscle, Skeletal - physiology
Nerve Growth Factors - biosynthesis
Nerve Tissue Proteins - biosynthesis
Neuroglia - metabolism
Neuroglia - physiology
Neurology
Neuromuscular Diseases - metabolism
Neuromuscular Diseases - physiopathology
Polymyositis
Regeneration - physiology
Reverse transcriptase-polymerase chain reaction
Skeletal muscle
Up-Regulation - physiology
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Summary:Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert a target-derived trophic factor for motor neurons. Immunohistochemical analyses revealed that expression of GDNF in regeneration muscle fibers was up-regulated in polymyositis (PM) and Duchenne type muscular dystrophy (DMD). Reverse transcriptase polymerase chain reaction (RT-PCR) analyses showed that the full length GDNF was up-regulated in PM and DMD muscle; normal muscle exhibited mostly truncated GDNF. The results indicate that the GDNF expression is regulated in regeneration of human skeletal muscle.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(98)00817-9