The influence of acute smoking on leucocytes, platelets and the endothelium

Cigarette smoking is a risk factor for the development of atherosclerosis. Possible mechanisms for this include leucocytes and platelet activation, and/or damage to the endothelium, any of which may contribute to changes in thrombosis and haemostasis. We examined the acute effects of smoking on thes...

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Bibliographic Details
Published in:Atherosclerosis 1998-11, Vol.141 (1), p.133-139
Main Authors: Blann, Andrew D, Kirkpatrick, Ursula, Devine, Carol, Naser, Salina, McCollum, Charles N
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Platelets - physiology
Endothelium, Vascular - metabolism
Female
Fibrinogen - analysis
Humans
Intercellular Adhesion Molecule-1 - blood
Leucocytes
Leukocyte Count
Leukocyte Elastase - blood
Male
Medical sciences
Middle Aged
Neutrophil Activation
Neutrophils
P-Selectin - blood
Platelet Activation
Platelet Count
Platelets
Smoking
Smoking - blood
Smoking - pathology
Tobacco, tobacco smoking
Toxicology
von Willebrand factor
von Willebrand Factor - analysis
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Summary:Cigarette smoking is a risk factor for the development of atherosclerosis. Possible mechanisms for this include leucocytes and platelet activation, and/or damage to the endothelium, any of which may contribute to changes in thrombosis and haemostasis. We examined the acute effects of smoking on these systems by obtaining blood before, immediately after, and at 10 and 30 min after the rapid smoking of two cigarettes in sequence by 20 smokers. Blood samples taken at the same time points from ten non-smokers acted as control material. In the smokers there was a transient rise in leucocyte count and neutrophil activation, but von Willebrand factor (VWF—marking endothelial damage) increased steadily at each time point ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(98)00163-4