Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival

Purpose: Tumor escape from host immune systems is a crucial mechanism for disease progression. We recently showed that the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is a prognostic indicator for endometrial cancer. The purpose of the present study was to investigate the relationship...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cancer research 2008-04, Vol.14 (8), p.2310-2317
Main Authors: INO, Kazuhiko, YAMAMOTO, Eiko, SHIBATA, Kiyosumi, KAJIYAMA, Hiroaki, YOSHIDA, Norio, TERAUCHI, Mikio, NAWA, Akihiro, NAGASAKA, Tetsuro, TAKIKAWA, Osamu, KIKKAWA, Fumitaka
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Biological and medical sciences
Disease Progression
endometrial cancer
Endometrial Neoplasms - enzymology
Endometrial Neoplasms - immunology
Endometrial Neoplasms - mortality
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
immunosuppression
indoleamine 2,3-dioxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis
Killer Cells, Natural - physiology
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating - physiology
Medical sciences
Middle Aged
Multivariate Analysis
Pharmacology. Drug treatments
progression-free survival
tumor-infiltrating lymphocytes
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: Tumor escape from host immune systems is a crucial mechanism for disease progression. We recently showed that the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is a prognostic indicator for endometrial cancer. The purpose of the present study was to investigate the relationship between IDO expression and tumor-infiltrating lymphocytes (TIL) or natural killer (NK) cells and to clarify their prognostic effect in endometrial cancer. Experimental Design: Immunohistochemical staining for IDO expression in endometrial cancer tissues ( n = 65) was done. Tumor-infiltrating CD3+ and CD8+ lymphocytes, as well as CD57+ NK cells, were counted in serial tissue sections. Results: High IDO expression in tumor cells was found in 32 of 65 cases and was positively correlated with myometrial invasion, nodal metastasis, and lymph-vascular space involvement. We also found a significant correlation between high IDO expression and reduced numbers of CD3+, CD8+, and CD57+ cells infiltrating into both the tumor epithelium and stroma. Patients with high IDO expression, a low number of stromal CD3 (
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-07-4144