Evaluation of service mammography screening impact in Italy. The contribution of hazard analysis

Abstract 12,987 invasive breast cancer cases were diagnosed in women aged 50–69 upto the year 2001 in nine Italian areas where a screening programme was active. Cases were followed up in 2005 for a total of 1921 breast cancer failures. The 10-year survival rates were 85.3% for the invited group agai...

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Bibliographic Details
Published in:European journal of cancer (1990) 2008-04, Vol.44 (6), p.858-865
Main Authors: Paci, Eugenio, Coviello, Enzo, Miccinesi, Guido, Puliti, Donella, Cortesi, Laura, Lisi, Vincenzo De, Ferretti, Stefano, Mangone, Lucia, Perlangeli, Vincenza, Ponti, Antonio, Ravaioli, Alessandra, de’ Bianchi, Priscilla Sassoli, Segnan, Nereo, Stracci, Fabrizio, Tumino, Rosario, Zarcone, Maurizio, Zorzi, Manuel, Zappa, Marco
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - mortality
Breast Neoplasms - prevention & control
Female
Hematology, Oncology and Palliative Medicine
Humans
Incidence
Italy - epidemiology
Mammography - mortality
Mammography - standards
Mass Screening - methods
Mass Screening - mortality
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Quality-Adjusted Life Years
Service screening
Survival
Survival Analysis
Tumors
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Summary:Abstract 12,987 invasive breast cancer cases were diagnosed in women aged 50–69 upto the year 2001 in nine Italian areas where a screening programme was active. Cases were followed up in 2005 for a total of 1921 breast cancer failures. The 10-year survival rates were 85.3% for the invited group against 75.6% for the non-invited. A time dependent analysis was performed using 5-year intervals. Crude hazard ratios for the invited group in comparison to the not invited group were 0.52 and 0.64 respectively in the (0–5) year and [5–10] year time windows. Hazard ratio adjusted for tumour characteristics was 0.96 in the [5–10] year time window, suggesting minimal or any length bias. Consistent with the results of randomised trials, these analyses of service screening data document a mortality reduction of 36% at 5–10 years after diagnosis.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2008.02.026