HLA-DQB10634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation

In this paper, we characterize the novel human leukocyte antigen (HLA)‐DQB1*0634 allele we found in a sibling pair during high‐resolution HLA typing in forecast of upcoming bone marrow transplantation. Both siblings, the female patient and her brother, were HLA identical, and therefore, both figured...

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Bibliographic Details
Published in:Tissue antigens 2008-05, Vol.71 (5), p.486-488
Main Authors: Witter, K., Albert, T., Zahn, R., Kauke, T.
Format: Article
Language:English
Subjects:
allele separation
Alleles
Amino Acid Substitution
Bone Marrow Transplantation
Female
Histocompatibility Testing
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
human leukocyte antigen-DQB1 exon 4
human leukocyte antigen-DQB10634
Humans
Male
Membrane Glycoproteins - genetics
Molecular Sequence Data
Siblings
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Summary:In this paper, we characterize the novel human leukocyte antigen (HLA)‐DQB1*0634 allele we found in a sibling pair during high‐resolution HLA typing in forecast of upcoming bone marrow transplantation. Both siblings, the female patient and her brother, were HLA identical, and therefore, both figured out the novel DQB1 allele characterized by a nucleotide exchange ‘C’ to ‘T’ at position 565, which is the last nucleotide of DQB1 exon 3. DQB1 exon 4 sequencing confirmed the exchange of codon 189‐arginine (CGG), which is replaced by tryptophan (TGG) in the new allele DQB1*0634.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2008.01021.x