Nonalcoholic fatty liver disease as a component of the metabolic syndrome

Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The association between NAFLD and the metabolic syndrome is well established: the presence of the metabolic syndrome signifies advanced histology in NAFLD patients. Emerging data indicate that pa...

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Bibliographic Details
Published in:Current gastroenterology reports 2008-02, Vol.10 (1), p.73-80
Main Authors: Khashab, Mouen A., Liangpunsakul, Suthat, Chalasani, Naga
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - complications
Fatty Liver - complications
Fatty Liver - epidemiology
Gastroenterology
Humans
Medicine
Medicine & Public Health
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Metabolic Syndrome - therapy
Obesity - complications
Obesity - therapy
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Summary:Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The association between NAFLD and the metabolic syndrome is well established: the presence of the metabolic syndrome signifies advanced histology in NAFLD patients. Emerging data indicate that patients with NAFLD have a significantly higher prevalence of cardiovascular disease. This article reviews the definitions of the two syndromes, their association, and the cardiovascular risk conferred by both when they occur separately and together. This review also discusses management options for the syndromes, including treating the individual components of the metabolic syndrome in NAFLD patients.
ISSN:1522-8037
1534-312X
DOI:10.1007/s11894-008-0012-0