cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene

A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22....

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Bibliographic Details
Published in:DNA research 1998, Vol.5 (5), p.309-313
Main Authors: Rigolet, M, Rich, T, Gross-Morand, M S, Molina-Gomes, D, Viegas-Pequignot, E, Junien, C
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Brain - metabolism
Chromosome Mapping
Chromosomes, Human, Pair 6
Cloning, Molecular
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
DNA-Binding Proteins
Fetus - metabolism
Gene Expression Regulation, Developmental
Humans
In Situ Hybridization, Fluorescence
Inhibitor of Differentiation Proteins
Mice
Molecular Sequence Data
Nervous System Neoplasms - genetics
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Sequence Analysis, DNA
Thyroid Gland - metabolism
Transcription Factors
Tumor Cells, Cultured
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Summary:A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22.3-p23. Northern blot analysis showed that ID4 is mainly expressed in thyroid, brain and fetal tissue and in some nervous system tumor cell lines.
ISSN:1340-2838
DOI:10.1093/dnares/5.5.309