Effective oral ganciclovir prophylaxis against cytomegalovirus disease in heart transplant recipients

The presented data show the combined sequential use of i.v. G for 14 days followed by PO G for 90 days is a much more effective prophylaxis for CMVD after heart transplantation than use of i.v. G for 14 days followed by PO A for 90 days. A need for hospitalization due to CMVD is significantly reduce...

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Bibliographic Details
Published in:Transplantation proceedings 1998-12, Vol.30 (8), p.4110-4112
Main Authors: Mullen, G.M, Silver, M.A, Malinowska, K, Lawless, C.E, Lichtenberg, R.C, Barath, P.C, O’Keefe, P.J, Robinson, J.A, Yeldandi, V
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Biological and medical sciences
Cytomegalovirus Infections - prevention & control
Drug Administration Schedule
Female
Ganciclovir - administration & dosage
Ganciclovir - therapeutic use
Heart Transplantation
Humans
Injections, Intravenous
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
Retrospective Studies
Time Factors
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Summary:The presented data show the combined sequential use of i.v. G for 14 days followed by PO G for 90 days is a much more effective prophylaxis for CMVD after heart transplantation than use of i.v. G for 14 days followed by PO A for 90 days. A need for hospitalization due to CMVD is significantly reduced by this new strategy. The follow-up in group II is shorter than in group I but is now at least 6 months in group II, without any new cases in the first 6 months after cardiac transplantation. Some currently unknown adverse effect of prolonged PO G, which may be present, is not identified in this analysis.
ISSN:0041-1345
1873-2623
DOI:10.1016/S0041-1345(98)01361-X