HNA-1a, HNA-1b and HNA-1c gene frequencies in Argentineans

• Published in: Tissue antigens 2008-05, Vol.71 (5), p.475-477
• Main Authors: La Vega Elena, C. D. de, Nogués, N., Fernández Montoya, A., Oyonarte, S., Solis, E., Muñiz-Díaz, E.
• Format: Article
• Language: English
• Subjects: Alleles; Argentina; Argentinean population; Ethnic Groups - genetics; gene frequencies; Gene Frequency; Genotype; HNA; human neutrophil antigens; Humans; Indians, South American - genetics; Isoantigens - genetics; Neutrophils - immunology
• ISSN: 0001-2815; 1399-0039
• DOI: 10.1111/j.1399-0039.2008.01034.x

Human neutrophil antigens (HNA) are polymorphic structures located in the neutrophil membrane. The neutrophil‐specific antigens HNA‐1a (NA1), 1b (NA2) and 1c (SH) are well‐recognized allotypic forms of FcγRIIIb and the most frequent targets of neutrophil alloantibodies. The aim of this study was to determine the gene frequencies of the neutrophil‐specific antigens belonging to the HNA‐1 system in blood donors and Toba Amerindians from Rosario, Argentina. Two hundred and eighteen unrelated healthy Argentinean blood donors and Toba Amerindians from Rosario were typed for HNA‐1a, HNA‐1b and HNA‐1c using polymerase chain reaction with sequence‐specific primers. For the Argentinean blood donors, the HNA‐1a and HNA‐1b gene frequencies were 0.44 and 0.56 and for the Amerindians Toba were 0.77 and 0.23, respectively. The HNA‐1c antigen is present in 4.7% (gene frequency = 0.023) of the blood donors but in none of the Amerindian individuals. The present data showed that the HNA‐1 allele frequencies in the major population and the Toba Amerindians from Rosario are similar to those described in European and others distant Amerindians populations, respectively.