High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes

A ‘combinatorial catalysis’ strategy was utilized to both rapidly synthesize organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficient...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-05, Vol.8 (10), p.1221-1224
Main Authors: Berg, Thorsten, Vandersteen, Anthony M., Janda, Kim D.
Format: Article
Language:English
Subjects:
Carboxylic Ester Hydrolases
Catalysis
Catalytic reactions
Chemistry
Exact sciences and technology
General and physical chemistry
Kinetics
Metals
Models, Molecular
Molecular Conformation
Organometallic Compounds - chemical synthesis
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:A ‘combinatorial catalysis’ strategy was utilized to both rapidly synthesize organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficiently. Metal complexes 1, developed by combinatorial chemistry, accelerate the hydrolysis of p-nitrophenyl carboxylic acid esters up to almost 5 times.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00199-1