Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene

Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting from L-xylose utilizing anomeric demethoxylation, Wittig reaction and Mitsunobu reaction as key steps and evaluated for antiviral activity. Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-04, Vol.8 (7), p.847-852
Main Authors: Jeong, Lak Shin, Yoo, Su Jeong
Format: Article
Language:English
Subjects:
Acyclovir - pharmacology
AIDS/HIV
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Survival - drug effects
Cytomegalovirus - drug effects
Dideoxynucleosides - chemical synthesis
Dideoxynucleosides - chemistry
Dideoxynucleosides - pharmacology
Drug Design
Ganciclovir - pharmacology
Herpesvirus 1, Human - drug effects
Herpesvirus 2, Human - drug effects
HIV-1 - drug effects
Humans
Hydrocarbons
Indicators and Reagents
Medical sciences
Methane - analogs & derivatives
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Structure-Activity Relationship
Xylose
Zidovudine - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting from L-xylose utilizing anomeric demethoxylation, Wittig reaction and Mitsunobu reaction as key steps and evaluated for antiviral activity. Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting from l-xylose utilizing demethoxylation, Wittig reaction and Mitsunobu reaction as key steps and evaluated for antiviral activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00122-X