Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects

Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The...

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Bibliographic Details
Published in:Amino acids 1998-09, Vol.15 (3), p.263-269
Main Authors: Fisher, G, Lorenzo, N, Abe, H, Fujita, E, Frey, W H, Emory, C, Di Fiore, M M, D' Aniello, A
Format: Article
Language:English
Subjects:
Alzheimer Disease - cerebrospinal fluid
Amino acids
Amino Acids - cerebrospinal fluid
Brain
Cerebrospinal fluid
Fluids
Humans
Repositories
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Summary:Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.
ISSN:0939-4451
1438-2199
DOI:10.1007/bf01318865