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Structure based design : Novel spirocyclic ethers as nonpeptidal P2-LIGANDS for HIV protease inhibitors
A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.
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| Published in: | Bioorganic & medicinal chemistry letters 1998-04, Vol.8 (8), p.979-982 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
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| Online Access: | Get full text |
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| cited_by | cdi_FETCH-LOGICAL-c314t-26317df7f92f8505ebe117073cd3eca4c10e9db76e42f7cbccf94b1183da84ca3 |
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| cites | cdi_FETCH-LOGICAL-c314t-26317df7f92f8505ebe117073cd3eca4c10e9db76e42f7cbccf94b1183da84ca3 |
| container_end_page | 982 |
| container_issue | 8 |
| container_start_page | 979 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | GHOSH, A. K KRISHNAN, K WALTERS, D. E WONHWA CHO CHO, H YUMEE KOO TREVINO, J HOLLAND, L BUTHOD, J |
| description | A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors. |
| doi_str_mv | 10.1016/s0960-894x(98)00139-5 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (8), p.979-982 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69111907 |
| source | Elsevier |
| subjects | AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Crystallography, X-Ray Drug Design Ethers, Cyclic - chemical synthesis Ethers, Cyclic - chemistry Ethers, Cyclic - pharmacology HIV Protease - metabolism HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 - enzymology Humans Kinetics Ligands Medical sciences Models, Molecular Molecular Conformation Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship |
| title | Structure based design : Novel spirocyclic ethers as nonpeptidal P2-LIGANDS for HIV protease inhibitors |
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