Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy

Background: Pain after laparoscopic cholecystectomy (LCC) is multifactorial. Effective post‐operative pain control is necessary in LCC performed as day‐case surgery. We studied the efficacy of paracetamol or valdecoxib with or without dexamethasone after LCC. Methods: One hundred sixty patients were...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2008-05, Vol.52 (5), p.673-680
Main Authors: TIIPPANA, E., BACHMANN, M., KALSO, E., PERE, P.
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Adolescent
Adult
Analgesics, Non-Narcotic - administration & dosage
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anti-Inflammatory Agents - administration & dosage
Biological and medical sciences
Cholecystectomy, Laparoscopic - adverse effects
Clinical Protocols
coxib
Cyclooxygenase Inhibitors - administration & dosage
dexamethasone
Dexamethasone - administration & dosage
Double-Blind Method
Female
Humans
Isoxazoles - administration & dosage
Laparoscopic cholecystectomy
Male
Medical sciences
Middle Aged
Oxycodone - administration & dosage
Pain Measurement
pain treatment
Pain, Postoperative - etiology
Pain, Postoperative - prevention & control
paracetamol
post-operative pain
Postoperative Nausea and Vomiting - prevention & control
Prospective Studies
Sulfonamides - administration & dosage
Time Factors
Treatment Outcome
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Summary:Background: Pain after laparoscopic cholecystectomy (LCC) is multifactorial. Effective post‐operative pain control is necessary in LCC performed as day‐case surgery. We studied the efficacy of paracetamol or valdecoxib with or without dexamethasone after LCC. Methods: One hundred sixty patients were randomized to four groups of 40 patients. Groups 1 and 3 received parecoxib 40 mg intravenously (IV) during surgery and valdecoxib 40 mg × 1 per os (PO) for 7 post‐operative days. Groups 2 and 4 received paracetamol 1 g × 4 IV during surgery and 1 g × 4 PO for 7 days. In addition, Groups 3 and 4 were given dexamethasone 10 mg IV intra‐operatively. Propofol and remifentanil were used during surgery. The patients were given oxycodone 0.05 mg/kg IV in phase 1 post‐anaesthesia care unit (PACU 1) or 0.15 mg/kg PO in phase 2 post‐anaesthesia care unit (PACU 2) as needed to keep visual analogue scale
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2008.01650.x