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Neuronorm is a potent and water soluble neurokinin A receptor antagonist
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharm...
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| Published in: | Bioorganic & medicinal chemistry letters 1998-07, Vol.8 (13), p.1735-1740 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c337t-dbabade62d16b49093c496d5635ecc6f8c257f8058af11205a839cb1511030803 |
| container_end_page | 1740 |
| container_issue | 13 |
| container_start_page | 1735 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | Lombardi, Angela D'Agostino, Bruno Filippelli, Amelia Pedone, Carlo Matera, Maria Gabriella Falciani, Maddalena De Rosa, Mario Rossi, Francesco Pavone, Vincenzo |
| description | We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named
Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in
in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
The synthesis and preliminary pharmacological characterization of
Neuronorm is reported. It represents a suitable candidate for therapeutic applications. |
| doi_str_mv | 10.1016/S0960-894X(98)00282-0 |
| format | article |
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Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in
in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
The synthesis and preliminary pharmacological characterization of
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Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in
in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
The synthesis and preliminary pharmacological characterization of
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Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in
in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
The synthesis and preliminary pharmacological characterization of
Neuronorm is reported. It represents a suitable candidate for therapeutic applications.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873425</pmid><doi>10.1016/S0960-894X(98)00282-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (13), p.1735-1740 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69113683 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Biological and medical sciences Guinea Pigs In Vitro Techniques Male Medical sciences Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Rats Receptors, Neurokinin-2 - antagonists & inhibitors Respiratory system Trachea - drug effects Vas Deferens - drug effects |
| title | Neuronorm is a potent and water soluble neurokinin A receptor antagonist |
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