PDE4 inhibitors: New xanthine analogues

Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline. A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by ( 3c), has been developed which displays activity both in vitro and in vivo.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (20), p.2925-2930
Main Authors: Montana, John G, Cooper, Nicola, Dyke, Hazel J, Gowers, Lewis, Gregory, Joanna P, Hellewell, Paul G, Miotla, Jadwiga, Morris, Ken, Naylor, Robert, Tuladhar, Bishwa, Warneck, Julie BH
Format: Article
Language:English
Subjects:
3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors
Animals
Biological and medical sciences
Cyclic Nucleotide Phosphodiesterases, Type 4
Eosinophilia - drug therapy
Ferrets
Guinea Pigs
Medical sciences
Pharmacology. Drug treatments
Phosphodiesterase Inhibitors - adverse effects
Phosphodiesterase Inhibitors - chemical synthesis
Phosphodiesterase Inhibitors - pharmacology
Respiratory system
Skin Diseases - drug therapy
Theophylline - pharmacology
Vomiting - chemically induced
Xanthines - chemical synthesis
Xanthines - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline. A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by ( 3c), has been developed which displays activity both in vitro and in vivo.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00524-1