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PDE4 inhibitors: New xanthine analogues
Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline. A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by ( 3c), has been developed which displays activity both in vitro and in vivo.
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| Published in: | Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (20), p.2925-2930 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c389t-59b89d9871f8b87c51437ebc2391a5d304c1e0ec86276feeee4451a5557e06a53 |
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| cites | cdi_FETCH-LOGICAL-c389t-59b89d9871f8b87c51437ebc2391a5d304c1e0ec86276feeee4451a5557e06a53 |
| container_end_page | 2930 |
| container_issue | 20 |
| container_start_page | 2925 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | Montana, John G Cooper, Nicola Dyke, Hazel J Gowers, Lewis Gregory, Joanna P Hellewell, Paul G Miotla, Jadwiga Morris, Ken Naylor, Robert Tuladhar, Bishwa Warneck, Julie BH |
| description | Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.
A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by (
3c), has been developed which displays activity both
in vitro and
in vivo. |
| doi_str_mv | 10.1016/S0960-894X(98)00524-1 |
| format | article |
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3c), has been developed which displays activity both
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A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by (
3c), has been developed which displays activity both
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A series of novel selective phosphodiesterase 4 (PDE4) inhibitors, exemplified by (
3c), has been developed which displays activity both
in vitro and
in vivo.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873649</pmid><doi>10.1016/S0960-894X(98)00524-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2925-2930 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69113723 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 4 Eosinophilia - drug therapy Ferrets Guinea Pigs Medical sciences Pharmacology. Drug treatments Phosphodiesterase Inhibitors - adverse effects Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - pharmacology Respiratory system Skin Diseases - drug therapy Theophylline - pharmacology Vomiting - chemically induced Xanthines - chemical synthesis Xanthines - pharmacology |
| title | PDE4 inhibitors: New xanthine analogues |
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