Synthesis of diacylamines and the preparation of α-amino-acylureas, a new type of α-amino acid derivatives

Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters. 16 new and 2 known open-chain diacylamines...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-11, Vol.8 (22), p.3241-3244
Main Authors: Weisz, Imre, Roboz, John, Wolf, Imre, Szabo, Jozsef, Bekesi, J.George
Format: Article
Language:English
Subjects:
Aliphatic compounds
Amines - chemical synthesis
Amino Acids - chemical synthesis
Anticonvulsants - pharmacology
Antineoplastic Agents - pharmacology
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
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Summary:Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters. 16 new and 2 known open-chain diacylamines were synthesized by Na-methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00593-9