Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (19), p.2653-2656
Main Authors: Medina, Julio C., Shan, Bei, Beckmann, Holger, Farrell, Robert P., Clark, David L., Marc Learned, R., Roche, Daniel, Li, Angela, Baichwal, Vijay, Case, Casey, Baeuerle, Patrick A., Rosen, Terry, Jaen, Juan C.
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Fluorobenzenes - pharmacology
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Phenotype
Sulfonamides - pharmacology
Tumor Cells, Cultured
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Summary:A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells. This article reports the discovery of a novel series of pentafluorobenzenesulfonamides as cytotoxic agents with efficacy againt a broad variety of human tumor cell lines, including those that exhibit the MDR phenotype.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00477-6