Studies of structure activity relationship of flavonoids for the anti-allergic actions

The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds t...

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Bibliographic Details
Published in:Archives of pharmacal research 1998-08, Vol.21 (4), p.478-480
Main Authors: Cheong, H, Ryu, S Y, Oak, M H, Cheon, S H, Yoo, G S, Kim, K M
Format: Article
Language:English
Subjects:
Animals
Anti-Allergic Agents - chemistry
Anti-Allergic Agents - pharmacology
beta-N-Acetylhexosaminidases - metabolism
Catechin - pharmacology
Cell Line
Flavonoids - chemistry
Flavonoids - pharmacology
Flavonols
Isoflavones - pharmacology
Molecular Structure
Rats
Structure-Activity Relationship
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Summary:The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02974647