Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii

Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha...

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Bibliographic Details
Published in:Archives of pharmacal research 1998-02, Vol.21 (1), p.67-69
Main Authors: Chae, S H, Kim, P S, Cho, J Y, Park, J S, Lee, J H, Yoo, E S, Baik, K U, Lee, J S, Park, M H
Format: Article
Language:English
Subjects:
Cell Line
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Humans
Macrophages - drug effects
Macrophages - metabolism
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).
ISSN:0253-6269
DOI:10.1007/BF03216755