Vascular Effects of Diet Supplementation With Plant Sterols

Vascular Effects of Diet Supplementation With Plant Sterols Oliver Weingärtner, Dieter Lütjohann, Shengbo Ji, Nicole Weisshoff, Franka List, Thomas Sudhop, Klaus von Bergmann, Karen Gertz, Jochem König, Hans-Joachim Schäfers, Matthias Endres, Michael Böhm, Ulrich Laufs This study investigates vascul...

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Published in:Journal of the American College of Cardiology 2008-04, Vol.51 (16), p.1553-1561
Main Authors: Weingärtner, Oliver, MD, Lütjohann, Dieter, PhD, Ji, Shengbo, Weisshoff, Nicole, List, Franka, Sudhop, Thomas, MD, von Bergmann, Klaus, MD, Gertz, Karen, MD, König, Jochem, PhD, Schäfers, Hans-Joachim, MD, Endres, Matthias, MD, Böhm, Michael, MD, Laufs, Ulrich, MD
Format: Article
Language:English
Subjects:
Aged
Animals
Arteriosclerosis - physiopathology
Arteriosclerosis - prevention & control
Atherosclerosis
Brain damage
Brain Ischemia - physiopathology
Brain Ischemia - prevention & control
Cardiology
Cardiovascular
Cardiovascular disease
Cardiovascular System - drug effects
Cholesterol
Diet
Dietary Supplements
Endothelium - physiopathology
Female
Functional foods & nutraceuticals
Humans
Internal Medicine
Ischemia
Male
Mice
Mice, Inbred C57BL
Phytosterols - administration & dosage
Phytosterols - blood
Phytosterols - pharmacology
Plant Preparations
Plasma
Risk Factors
Rodents
Smooth muscle
Sterols
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Summary:Vascular Effects of Diet Supplementation With Plant Sterols Oliver Weingärtner, Dieter Lütjohann, Shengbo Ji, Nicole Weisshoff, Franka List, Thomas Sudhop, Klaus von Bergmann, Karen Gertz, Jochem König, Hans-Joachim Schäfers, Matthias Endres, Michael Böhm, Ulrich Laufs This study investigates vascular effects of diet supplementation with plant sterol esters. In mice, plant sterol supplementation impairs endothelial function, aggravates ischemic brain injury, and affects atherogenesis. In humans, a sterol-rich diet leads to increased tissue sterol concentrations. Therefore, prospective studies are warranted that evaluate not only effects on cholesterol reduction but also on clinical end points.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.09.074