Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms

This article highlights the recent advances in our understanding of the molecular structure and function of proteins that are activated or created by chromosomal abnormalities and discusses their possible role in tumor development. The molecular characterization of these proteins has revealed that t...

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Bibliographic Details
Published in:BioEssays 1998-11, Vol.20 (11), p.922-930
Main Authors: Cobaleda, C., Pérez-Losada, J., Sánchez-García, I.
Format: Article
Language:English
Subjects:
Apoptosis
Artificial Gene Fusion
Chimera
Chromosome Aberrations
Chromosome Disorders
Gene Expression Regulation
Humans
Models, Genetic
Neoplasms - genetics
Neoplasms - therapy
Transcription Factors - genetics
Translocation, Genetic
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Summary:This article highlights the recent advances in our understanding of the molecular structure and function of proteins that are activated or created by chromosomal abnormalities and discusses their possible role in tumor development. The molecular characterization of these proteins has revealed that tumor‐specific fusion proteins are the consequence of the majority of chromosomal translocations associated with leukemias and solid tumors. A common theme that emerges is that creation of these proteins disrupts the normal development of tumor‐specific target cells by blocking apoptosis. These insights identify these chromosomal translocation‐associated genes as potential targets for improved cancer therapies. BioEssays 20:922–930, 1998. © 1998 John Wiley & Sons, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/(SICI)1521-1878(199811)20:11<922::AID-BIES7>3.0.CO;2-O