Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate ( 1), rosmarinic acid ( 2) and methyl rosmarinate ( 3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2008-05, Vol.15 (5), p.386-388
Main Authors: Li, Q.-L., Li, B.-G., Zhang, Y., Gao, X.-P., Li, C.-Q., Zhang, G.-L.
Format: Article
Language:English
Subjects:
ACE inhibitors
Angiotensin-converting enzyme inhibitor
Angiotensin-Converting Enzyme Inhibitors - chemistry
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Antihypertensive drugs
Caffeic Acids - chemistry
Caffeic Acids - pharmacology
Chemical properties
Cinnamates - chemistry
Cinnamates - pharmacology
Depsides - chemistry
Depsides - pharmacology
Dosage and administration
Health aspects
Isodon - chemistry
Lamiaceae
Lung - enzymology
Peptidyl-Dipeptidase A - drug effects
Peptidyl-Dipeptidase A - isolation & purification
Peptidyl-Dipeptidase A - metabolism
Plant Extracts - chemistry
Plant Extracts - pharmacology
Production processes
Rabbits
Rabdosia coetsa
Rosmarinic Acid
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Summary:The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate ( 1), rosmarinic acid ( 2) and methyl rosmarinate ( 3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 μg/ml.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2007.09.013