Potent HIV protease inhibitors incorporating high-affinity P2-LIGANDS and (R)-(hydroxyethylamino)sulfonamide isostere

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-03, Vol.8 (6), p.687-690
Main Authors: GHOSH, A. K, KINCAID, J. F, BUTHOD, J, WONHWA CHO, WALTERS, D. E, KRISHNAN, K, KHAJA AZHAR HUSSAIN, YUMEE KOO, CHO, H, RUDALL, C, HOLLAND, L
Format: Article
Language:English
Subjects:
AIDS/HIV
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Cell Line
Drug Design
HIV Protease Inhibitors - chemical synthesis
Humans
Ligands
Medical sciences
Models, Chemical
Pharmacology. Drug treatments
Saquinavir - analogs & derivatives
Saquinavir - chemistry
Sulfonamides - chemistry
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Description
Summary:Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
ISSN:0960-894X
1464-3405
DOI:10.1016/s0960-894x(98)00098-5