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Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome
Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published repo...
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Published in: | Multiple sclerosis 2008-04, Vol.14 (3), p.425-427 |
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container_title | Multiple sclerosis |
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creator | Mehta, Lahar R Samuelsson, Melissa K Kleiner, Anatole K Goodman, Andrew D Anolik, Jennifer H Looney, R John Schwid, Steven R |
description | Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy. Multiple Sclerosis 2008; 14: 425—427. http://msj.sagepub.com |
doi_str_mv | 10.1177/1352458507084107 |
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NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy. Multiple Sclerosis 2008; 14: 425—427. http://msj.sagepub.com</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458507084107</identifier><identifier>PMID: 18208886</identifier><identifier>CODEN: MUSCFZ</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antiphospholipid Syndrome - complications ; Antiphospholipid Syndrome - immunology ; Antiphospholipid Syndrome - pathology ; Aquaporin 4 - immunology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Immunoglobulin G - blood ; Lupus Vasculitis, Central Nervous System - complications ; Lupus Vasculitis, Central Nervous System - immunology ; Lupus Vasculitis, Central Nervous System - pathology ; Magnetic Resonance Imaging ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Myelitis, Transverse - complications ; Myelitis, Transverse - immunology ; Myelitis, Transverse - pathology ; Neurology ; Neuromyelitis Optica - complications ; Neuromyelitis Optica - immunology ; Neuromyelitis Optica - pathology ; Prognosis</subject><ispartof>Multiple sclerosis, 2008-04, Vol.14 (3), p.425-427</ispartof><rights>2008 INIST-CNRS</rights><rights>SAGE Publications © Apr 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-a3d960c46369bce94ad94557df868aae66765968e0c3b771b4259bc454aedc4e3</citedby><cites>FETCH-LOGICAL-c392t-a3d960c46369bce94ad94557df868aae66765968e0c3b771b4259bc454aedc4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20332359$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18208886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Lahar R</creatorcontrib><creatorcontrib>Samuelsson, Melissa K</creatorcontrib><creatorcontrib>Kleiner, Anatole K</creatorcontrib><creatorcontrib>Goodman, Andrew D</creatorcontrib><creatorcontrib>Anolik, Jennifer H</creatorcontrib><creatorcontrib>Looney, R John</creatorcontrib><creatorcontrib>Schwid, Steven R</creatorcontrib><title>Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy. Multiple Sclerosis 2008; 14: 425—427. http://msj.sagepub.com</description><subject>Antiphospholipid Syndrome - complications</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Antiphospholipid Syndrome - pathology</subject><subject>Aquaporin 4 - immunology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Lupus Vasculitis, Central Nervous System - complications</subject><subject>Lupus Vasculitis, Central Nervous System - immunology</subject><subject>Lupus Vasculitis, Central Nervous System - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Myelitis, Transverse - complications</subject><subject>Myelitis, Transverse - immunology</subject><subject>Myelitis, Transverse - pathology</subject><subject>Neurology</subject><subject>Neuromyelitis Optica - complications</subject><subject>Neuromyelitis Optica - immunology</subject><subject>Neuromyelitis Optica - pathology</subject><subject>Prognosis</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kUtr3TAQhU1paR7tvqsiCs3OqWS9lyX0BaHZpGsjS3N7FWzL1cgEL_Lfq3AvDQS6GPSY78wZOE3zjtFLxrT-xLjshDSSamoEo_pFc8qE1i21mr6s99puH_snzRniHaVUay5fNyfMdNQYo06bh5-w5jRtMMYSkaSlRO8ILuBLXicSIqYcIJM4E0cWVyLMhdzHsie4YYEpejKuy4oE8lb2MLmSsL7cHGqV2C77hLXGuMTDz5DCVrVzqK7wpnm1cyPC2-N53vz6-uX26nt7ffPtx9Xn69Zz25XW8WAV9UJxZQcPVrhghZQ67IwyzoFSWkmrDFDPB63ZIDpZQSGFg-AF8PPm4jB3yenPClj6KaKHcXQzpBV7ZRkzSooKfngG3qU1z3W3vmPGUM6trBA9QD4nxAy7fslxcnnrGe0fc-mf51Il749z12GC8CQ4BlGBj0fAoXfjLrvZR_zHddW549JWrj1w6H7D03L_Nf4LHv6kxw</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Mehta, Lahar R</creator><creator>Samuelsson, Melissa K</creator><creator>Kleiner, Anatole K</creator><creator>Goodman, Andrew D</creator><creator>Anolik, Jennifer H</creator><creator>Looney, R John</creator><creator>Schwid, Steven R</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome</title><author>Mehta, Lahar R ; Samuelsson, Melissa K ; Kleiner, Anatole K ; Goodman, Andrew D ; Anolik, Jennifer H ; Looney, R John ; Schwid, Steven R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-a3d960c46369bce94ad94557df868aae66765968e0c3b771b4259bc454aedc4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antiphospholipid Syndrome - complications</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Antiphospholipid Syndrome - pathology</topic><topic>Aquaporin 4 - immunology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Lupus Vasculitis, Central Nervous System - complications</topic><topic>Lupus Vasculitis, Central Nervous System - immunology</topic><topic>Lupus Vasculitis, Central Nervous System - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Myelitis, Transverse - complications</topic><topic>Myelitis, Transverse - immunology</topic><topic>Myelitis, Transverse - pathology</topic><topic>Neurology</topic><topic>Neuromyelitis Optica - complications</topic><topic>Neuromyelitis Optica - immunology</topic><topic>Neuromyelitis Optica - pathology</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, Lahar R</creatorcontrib><creatorcontrib>Samuelsson, Melissa K</creatorcontrib><creatorcontrib>Kleiner, Anatole K</creatorcontrib><creatorcontrib>Goodman, Andrew D</creatorcontrib><creatorcontrib>Anolik, Jennifer H</creatorcontrib><creatorcontrib>Looney, R John</creatorcontrib><creatorcontrib>Schwid, Steven R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, Lahar R</au><au>Samuelsson, Melissa K</au><au>Kleiner, Anatole K</au><au>Goodman, Andrew D</au><au>Anolik, Jennifer H</au><au>Looney, R John</au><au>Schwid, Steven R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>14</volume><issue>3</issue><spage>425</spage><epage>427</epage><pages>425-427</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><coden>MUSCFZ</coden><abstract>Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy. Multiple Sclerosis 2008; 14: 425—427. http://msj.sagepub.com</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>18208886</pmid><doi>10.1177/1352458507084107</doi><tpages>3</tpages></addata></record> |
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subjects | Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - immunology Antiphospholipid Syndrome - pathology Aquaporin 4 - immunology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Immunoglobulin G - blood Lupus Vasculitis, Central Nervous System - complications Lupus Vasculitis, Central Nervous System - immunology Lupus Vasculitis, Central Nervous System - pathology Magnetic Resonance Imaging Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelitis, Transverse - complications Myelitis, Transverse - immunology Myelitis, Transverse - pathology Neurology Neuromyelitis Optica - complications Neuromyelitis Optica - immunology Neuromyelitis Optica - pathology Prognosis |
title | Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome |
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