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Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome

Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published repo...

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Published in:Multiple sclerosis 2008-04, Vol.14 (3), p.425-427
Main Authors: Mehta, Lahar R, Samuelsson, Melissa K, Kleiner, Anatole K, Goodman, Andrew D, Anolik, Jennifer H, Looney, R John, Schwid, Steven R
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description Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system characterized by severe episodes of optic nerve and spinal cord inflammation. NMO-IgG (anti-aquaporin-4) has been recently described as a sensitive and specific marker for NMO. As there have been prior published reports of an association between NMO and systemic autoimmune diseases, the prognostic value of the antibody test in these cases is uncertain. We describe a 47-year old woman with recurrent transverse myelitis and a long-standing history of systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APLS). While she did not have a history of optic neuritis, serological testing for the NMO-IgG was positive when she was admitted for her second episode of transverse myelitis. Testing for the NMO-IgG in cases of isolated or recurrent transverse myelitis attributed to current SLE and APLS may help clarify the diagnosis of a distinct disease process likely to cause recurrent and severe disability, warranting more aggressive immunotherapy. Multiple Sclerosis 2008; 14: 425—427. http://msj.sagepub.com
doi_str_mv 10.1177/1352458507084107
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subjects Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - immunology
Antiphospholipid Syndrome - pathology
Aquaporin 4 - immunology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Immunoglobulin G - blood
Lupus Vasculitis, Central Nervous System - complications
Lupus Vasculitis, Central Nervous System - immunology
Lupus Vasculitis, Central Nervous System - pathology
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Myelitis, Transverse - complications
Myelitis, Transverse - immunology
Myelitis, Transverse - pathology
Neurology
Neuromyelitis Optica - complications
Neuromyelitis Optica - immunology
Neuromyelitis Optica - pathology
Prognosis
title Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome
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