Oncological safety and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction

• Published in: Surgical oncology 2008-08, Vol.17 (2), p.97-105
• Main Authors: Patani, N, Devalia, H, Anderson, A, Mokbel, K
• Format: Article
• Language: English
• Subjects: Adult; Aged; Breast cancer; Breast Implants; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cancer therapies; Cohort Studies; Ductal carcinoma in situ; Female; Hematology, Oncology and Palliative Medicine; Humans; Immediate breast reconstruction; Mammaplasty; Mammography; Mastectomy; Mastectomy, Subcutaneous; Middle Aged; Morbidity; Outcome; Patient Satisfaction; Radiation therapy; Recurrence; Retrospective Studies; Satisfaction; Skin-sparing mastectomy; Surgery; Surgical Flaps; Therapy; Transplants & implants; Treatment Outcome
• ISSN: 0960-7404; 1879-3320
• DOI: 10.1016/j.suronc.2007.11.004

Summary Introduction The management of early breast cancer with skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is not based on evidence from randomised controlled trials. The purpose of this study is to evaluate the oncological safety, post-operative morbidity and patients’ satisfaction with SSM and IBR using the latissimus dorsi (LD) myocutaneous flap and/or breast prosthesis. Methods Eighty-three consecutive women underwent 93 SSMs with IBR (10 bilateral), using the LD flap plus implant ( n =55) or implant alone ( n =38), indications included early breast cancer and prophylaxis due to BRCA-1 gene mutation. Nipple reconstruction was performed in 38 patients, using the trefoil local flap technique, nipple sharing or Monocryl mesh. Twenty-three underwent contra-lateral surgery in order to optimise symmetry, including 15 augmentations and eight mastopexy/reduction mammoplasties. Patient satisfaction with the outcome of surgery was assessed on a linear visual analogue scale ranging from 0 (not satisfied) to 10 (most satisfied). Results There was no local recurrence (LR) after a median follow-up of 34 months (range=3–79 months). Overall survival was 98.8%, three patients developed distant disease and one patient died of metastatic breast cancer. No case of partial or total LD flap loss was observed. Morbidities included infection, requiring implant removal in two patients and one patient developed marginal ischaemia of the skin envelope. Significant capsule formation, requiring capsulotomy, was observed in 87% of patients who had either PMR or prior RT compared with 13% for those who did not have RT. Sixty-one (73.5%) of 83 patients completed the questionnaire with a median and mean satisfaction scores of 10.0 and 9.3, respectively (range=6–10). Conclusion SSM with IBR is associated with low morbidity, high levels of patient satisfaction and is oncologically adequate for Tis , T1 and T2 tumours without extensive skin involvement.