Are Hormonal Responses to Exercise in Young Men with Down's Syndrome Related to Reduced Endurance Performance?

The aim of the present study was to analyse whether hormonal responses could explain an exercise limitation in Down’s syndrome (DS). Fourteen young men with DS (mean age 22.5 ± 0.7 years) and 15 controls (CONT, mean age 22.5 ± 0.3 years) participated in the study. During a treadmill submaximal incre...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2008-05, Vol.20 (5), p.558-565
Main Authors: Bricout, V-A., Guinot, M., Faure, P., Flore, P., Eberhard, Y., Garnier, P., Favre Juvin, A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Composition
Body Height
Catecholamines - blood
Chromosome aberrations
Down Syndrome - blood
Down Syndrome - metabolism
Down Syndrome - physiopathology
endurance
Exercise - physiology
Exercise Test
Fatty Acids, Nonesterified - blood
Fundamental and applied biological sciences. Psychology
hormones
Hormones - blood
Hormones - metabolism
Humans
Hydrocortisone - blood
Leptin - blood
Male
Medical genetics
Medical sciences
muscular exercise
Physical Endurance - physiology
trisomy 21
Vertebrates: endocrinology
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Summary:The aim of the present study was to analyse whether hormonal responses could explain an exercise limitation in Down’s syndrome (DS). Fourteen young men with DS (mean age 22.5 ± 0.7 years) and 15 controls (CONT, mean age 22.5 ± 0.3 years) participated in the study. During a treadmill submaximal incremental test, blood samples were collected for determination of hormonal and metabolic variables. Compared to CONT, DS individuals showed lower VO2max (P 
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2008.01695.x