DNA-based typing of Kell, Kidd, MNS, Dombrock, Colton, and Yt blood group systems in the French Basques

The Basques demonstrate peculiar characteristics regarding blood group systems. Although ABO, Rhesus, and Duffy have been extensively studied in this population, the distribution of other groups remains largely unknown. Therefore, we evaluated the frequency of less‐explored‐ or still noninvestigated...

Full description

Saved in:
Bibliographic Details
Published in:American journal of human biology 2008-05, Vol.20 (3), p.308-311
Main Authors: Touinssi, Mhammed, Chiaroni, Jacques, Degioanni, Anna, Granier, Thomas, Dutour, Olivier, Bailly, Pascal, Bauduer, Frédéric
Format: Article
Language:English
Subjects:
Alleles
Blood Group Antigens - genetics
DNA Fingerprinting
Female
France - ethnology
Gene Amplification
Gene Frequency
Genetics, Population
Genotype
Humans
Kell Blood-Group System - genetics
Kidd Blood-Group System - genetics
Male
MNSs Blood-Group System - genetics
Polymorphism, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Basques demonstrate peculiar characteristics regarding blood group systems. Although ABO, Rhesus, and Duffy have been extensively studied in this population, the distribution of other groups remains largely unknown. Therefore, we evaluated the frequency of less‐explored‐ or still noninvestigated blood groups using DNA‐based assays and interpreted these data in the view of population genetics. Polymorphisms of KEL (Kell), SLCA14A1 (Kidd), GYPA/GYPB (MNS), ART4 (Dombrock), AQP1 (Colton), and ACHE (Yt) blood group genes were determined from a sample of more than 100 autochthonous French Basques using allele‐specific primer PCR (PCR‐ASP) methods. Our results were compared with those previously obtained by the use of serology from both Basque and nonBasque European populations. MNS*1 and JK*1 allele frequencies were comparable with those reported from Basque samples. Conversely, the KEL*1 allele frequency differed significantly. To our knowledge, this is the first time that the other three systems are studied in the Basque population. DO*1 and CO*1 allele frequencies, being respectively 0.35 and 0.96, were significantly inferior to those published from various European populations. There were some discrepancies regarding these six blood systems when comparing molecular typing with serology. These findings may be explained by differences in either criteria for individual selection or technical assays. Nevertheless, these results constitute additional data to be included in the chapter of Basque biological anthropology. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.
ISSN:1042-0533
1520-6300
DOI:10.1002/ajhb.20720