Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure?: Assessment of autonomic modulation with heart rate variability

Autonomic dysfunction seems to be involved in the progression and prognosis of congestive heart failure. Measurement of heart rate variability (HRV) provides a noninvasive method to obtain reliable and reproducible information on autonomic modulation of heart rate, but there is a difficulty in using...

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Bibliographic Details
Published in:International journal of cardiology 1998-11, Vol.67 (1), p.9-17
Main Authors: Scalvini, Simonetta, Volterrani, Maurizio, Zanelli, Emanuela, Pagani, Marco, Mazzuero, Giorgio, Coats, Andrew J, Giordano, Amerigo
Format: Article
Language:English
Subjects:
Autonomic Nervous System - physiopathology
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Chronic heart failure
Electrocardiography - methods
Female
Heart
Heart - innervation
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart Rate - physiology
Heart rate variability
Humans
Left ventricular dysfunction
Male
Medical sciences
Middle Aged
Signal Processing, Computer-Assisted
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - physiopathology
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Summary:Autonomic dysfunction seems to be involved in the progression and prognosis of congestive heart failure. Measurement of heart rate variability (HRV) provides a noninvasive method to obtain reliable and reproducible information on autonomic modulation of heart rate, but there is a difficulty in using HRV as a quantitative estimate of autonomic dysfunction in heart failure. This study was aimed at testing the hypothesis that abnormal modulation of heart rate assessed by power spectrum analysis may be present also in asymptomatic patients with left ventricular dysfunction and progress in patients with overt symptoms of congestive heart failure. HRV was measured in three groups of subjects: Group 1: 30 patients with chronic heart failure; Group 2: 21 patients with asymptomatic left ventricular dysfunction; and Group 3: 25 healthy volunteers as control group. HRV was evaluated by autoregressive spectral analysis with 600-beat ECG samples, while subjects were quietly recumbent (BS1), in conditions of controlled breathing (15 acts/min) (RSC) and passive orthostatism after tilting (80°) (TLT). Patients in group 1 showed a reduction in the standard deviation of the R–R intervals (SDRR) ( p
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(98)00252-6