Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves

The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electro...

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Bibliographic Details
Published in:Regulatory peptides 1998-11, Vol.78 (1), p.113-123
Main Authors: Zabielski, Romuald, Leśniewska, Violetta, Borlak, Jürgen, Gregory, Peter C, Kiela, Paweł, Pierzynowski, Stefan G, Barej, Wiesław
Format: Article
Language:English
Subjects:
Animals
Atropine
Atropine - pharmacology
Benzodiazepines - pharmacology
Biological and medical sciences
Cattle
CCK-A receptor antagonist
Cholecystokinin
Electromyography - drug effects
Electrophysiology
Exocrine pancreas
Fundamental and applied biological sciences. Psychology
Gastrointestinal Motility - drug effects
Male
Migrating myoelectric complex
Pancreas - drug effects
Pancreas - metabolism
Pancreatic Juice - drug effects
Periodic pancreatic secretion
Receptor, Cholecystokinin A
Receptors, Cholecystokinin - antagonists & inhibitors
Sincalide - blood
Sincalide - pharmacology
Vertebrates: digestive system
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Summary:The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms.
ISSN:0167-0115
1873-1686
DOI:10.1016/S0167-0115(98)00139-6