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Vaccination with a Plasmodium chabaudi adami multivalent DNA vaccine cross-protects A/J mice against challenge with P. c. adami DK and virulent Plasmodium chabaudi chabaudi AS parasites
A current goal of malaria vaccine research is the development of vaccines that will cross-protect against multiple strains of malaria. In the present study, the breadth of cross-reactivity induced by a 30K multivalent DNA vaccine has been evaluated in susceptible A/J mice (H-2a) against infection wi...
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Published in: | International journal for parasitology 2008-06, Vol.38 (7), p.819-827 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A current goal of malaria vaccine research is the development of vaccines that will cross-protect against multiple strains of malaria. In the present study, the breadth of cross-reactivity induced by a 30K multivalent DNA vaccine has been evaluated in susceptible A/J mice (H-2a) against infection with the
Plasmodium chabaudi adami DK strain and a virulent parasite subspecies,
Plasmodium chabaudi chabaudi AS. Immunized A/J mice were significantly protected against infection with both
P. c. adami DK (31–40% reduction in cumulative parasitemia) and
P. c. chabaudi AS parasites, where a 30–39% reduction in cumulative parasitemia as well as enhanced survival was observed. The 30K vaccine-induced specific IFN-γ production by splenocytes in response to native antigens from both
P. c. chabaudi AS and
P. c. adami DK. Specific antibodies reacting with surface antigens expressed on
P. c. adami DS and
P. c. chabaudi AS infected red blood cells, and with opsonizing properties, were detected. These results suggest that multivalent vaccines encoding conserved antigens can feasibly induce immune cross-reactivity that span
Plasmodium strains and subspecies and can protect hosts of distinct major histocompatibility complex haplotypes. |
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ISSN: | 0020-7519 1879-0135 |
DOI: | 10.1016/j.ijpara.2007.10.009 |