Sympatho-adrenal involvement in methamphetamine-induced hyperthermia through skeletal muscle hypermetabolism

We investigated the involvement of the sympatho-adrenal axis in the hyperthermia induced by methamphetamine by using a biotelemetric system. The intraperitoneal injection of methamphetamine (1 mg/kg) induced hyperthermia preceded by an increase in oxygen consumption in freely moving rats. The hypert...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 1998-12, Vol.363 (2), p.107-112
Main Authors: Makisumi, Toshirou, Yoshida, Ken-ichi, Watanabe, Tatsuo, Tan, Nobusuke, Murakami, Naotoshi, Morimoto, Akio
Format: Article
Language:English
Subjects:
Adrenal gland
Adrenal Glands - physiopathology
Adrenalectomy
Animals
Biological and medical sciences
Body Temperature
Drug addictions
Fever - chemically induced
Fever - physiopathology
Glucocorticoid
Hyperthermia
Male
Medical sciences
Methamphetamine
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Oxygen Consumption
Rats
Rats, Wistar - surgery
Sympathectomy
Sympathetic nerve system
Sympathetic Nervous System - physiopathology
Time Factors
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the involvement of the sympatho-adrenal axis in the hyperthermia induced by methamphetamine by using a biotelemetric system. The intraperitoneal injection of methamphetamine (1 mg/kg) induced hyperthermia preceded by an increase in oxygen consumption in freely moving rats. The hyperthermic effect of methamphetamine was completely blocked by chemical sympathectomy with 6-hydroxydopamine (50 mg/kg, i.p.). Adrenalectomy, but not adrenal demedullation, prevented the hyperthermia. In adrenalectomized rats, dexamethasone supplementation (0.5 mg/kg, s.c.) restored the methamphetamine-induced hyperthermia. Furthermore, dantrolene (1 or 2 mg/kg, i.v.), which blocks Ca 2+ release from the sarcoplasmic reticulum in skeletal muscle, attenuated the hyperthermia. These results suggest that methamphetamine stimulates norepinephrine release from sympathetic nerve terminals, which then enhances thermogenesis in skeletal muscle under the permissive action of glucocorticoids.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(98)00758-4