Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitub...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-04, Vol.16 (8), p.4516-4522
Main Authors: ZAMPIERI, Daniele, GRAZIAMAMOLO, Maria, LAURINI, Erik, SCIALINO, Giuditta, BANFI, Elena, VIO, Luciano
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Hydrogen - chemistry
Imidazoles - chemical synthesis
Imidazoles - chemistry
Imidazoles - pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Mycobacterium tuberculosis - drug effects
Pharmacology. Drug treatments
Pyrazoles - chemistry
Structure-Activity Relationship
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Summary:1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2008.02.055