Loading…

Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitub...

Full description

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry 2008-04, Vol.16 (8), p.4516-4522
Main Authors:	ZAMPIERI, Daniele, GRAZIAMAMOLO, Maria, LAURINI, Erik, SCIALINO, Giuditta, BANFI, Elena, VIO, Luciano
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Candida albicans - drug effects Hydrogen - chemistry Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Pyrazoles - chemistry Structure-Activity Relationship
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13
cites	cdi_FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13
container_end_page	4522
container_issue	8
container_start_page	4516
container_title	Bioorganic & medicinal chemistry
container_volume	16
creator	ZAMPIERI, Daniele GRAZIAMAMOLO, Maria LAURINI, Erik SCIALINO, Giuditta BANFI, Elena VIO, Luciano
description	1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.
doi_str_mv	10.1016/j.bmc.2008.02.055
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69127576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69127576</sourcerecordid><originalsourceid>FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13</originalsourceid><addsrcrecordid>eNpFkM1KJDEUhYM4aNvOA7iR3igKk5rcJJVKlo2MPyDMZlyHVJLSNPXTJtVC-fST0kYDIeHj3AP3Q-gMSAEExO9NUXe2oITIgtCClOUBWgAXHDOm4BAtiBISE6nEMTpJaUMIoVzBEToGyShUwBdou-7H0Oz6Z9OuTO_yHUM32aE2dvQxzNSO4S2M02poVoCv2K8Su2Di1GL-8X2ZXBww3OPtFM37kDGe2usZhC64mfiVy1VvJvf4dIp-NKZN_uf-XaKn2z__bu7x49-7h5v1I7aMqhGrSnohGFRcAFUOGPPAaOlUPhnLzB0Y0liruK9pXfKqLiWtG1vVTFhgS3T52buNw-vOp1F3IVnftqb3wy5poYBWZSVyED6DNg4pRd_obQxdXlAD0bNmvdFZs541a0J11pxnzvflu7rz7nti7zUHLvYBk6xpm2h6G9JXjhJGJWeS_QcN9ISF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69127576</pqid></control><display><type>article</type><title>Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives</title><source>ScienceDirect Freedom Collection</source><creator>ZAMPIERI, Daniele ; GRAZIAMAMOLO, Maria ; LAURINI, Erik ; SCIALINO, Giuditta ; BANFI, Elena ; VIO, Luciano</creator><creatorcontrib>ZAMPIERI, Daniele ; GRAZIAMAMOLO, Maria ; LAURINI, Erik ; SCIALINO, Giuditta ; BANFI, Elena ; VIO, Luciano</creatorcontrib><description>1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2008.02.055</identifier><identifier>PMID: 18321714</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Biological and medical sciences ; Candida albicans - drug effects ; Hydrogen - chemistry ; Imidazoles - chemical synthesis ; Imidazoles - chemistry ; Imidazoles - pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Mycobacterium tuberculosis - drug effects ; Pharmacology. Drug treatments ; Pyrazoles - chemistry ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry, 2008-04, Vol.16 (8), p.4516-4522</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13</citedby><cites>FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20328438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18321714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAMPIERI, Daniele</creatorcontrib><creatorcontrib>GRAZIAMAMOLO, Maria</creatorcontrib><creatorcontrib>LAURINI, Erik</creatorcontrib><creatorcontrib>SCIALINO, Giuditta</creatorcontrib><creatorcontrib>BANFI, Elena</creatorcontrib><creatorcontrib>VIO, Luciano</creatorcontrib><title>Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - drug effects</subject><subject>Hydrogen - chemistry</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrazoles - chemistry</subject><subject>Structure-Activity Relationship</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkM1KJDEUhYM4aNvOA7iR3igKk5rcJJVKlo2MPyDMZlyHVJLSNPXTJtVC-fST0kYDIeHj3AP3Q-gMSAEExO9NUXe2oITIgtCClOUBWgAXHDOm4BAtiBISE6nEMTpJaUMIoVzBEToGyShUwBdou-7H0Oz6Z9OuTO_yHUM32aE2dvQxzNSO4S2M02poVoCv2K8Su2Di1GL-8X2ZXBww3OPtFM37kDGe2usZhC64mfiVy1VvJvf4dIp-NKZN_uf-XaKn2z__bu7x49-7h5v1I7aMqhGrSnohGFRcAFUOGPPAaOlUPhnLzB0Y0liruK9pXfKqLiWtG1vVTFhgS3T52buNw-vOp1F3IVnftqb3wy5poYBWZSVyED6DNg4pRd_obQxdXlAD0bNmvdFZs541a0J11pxnzvflu7rz7nti7zUHLvYBk6xpm2h6G9JXjhJGJWeS_QcN9ISF</recordid><startdate>20080415</startdate><enddate>20080415</enddate><creator>ZAMPIERI, Daniele</creator><creator>GRAZIAMAMOLO, Maria</creator><creator>LAURINI, Erik</creator><creator>SCIALINO, Giuditta</creator><creator>BANFI, Elena</creator><creator>VIO, Luciano</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080415</creationdate><title>Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives</title><author>ZAMPIERI, Daniele ; GRAZIAMAMOLO, Maria ; LAURINI, Erik ; SCIALINO, Giuditta ; BANFI, Elena ; VIO, Luciano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Candida albicans - drug effects</topic><topic>Hydrogen - chemistry</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrazoles - chemistry</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAMPIERI, Daniele</creatorcontrib><creatorcontrib>GRAZIAMAMOLO, Maria</creatorcontrib><creatorcontrib>LAURINI, Erik</creatorcontrib><creatorcontrib>SCIALINO, Giuditta</creatorcontrib><creatorcontrib>BANFI, Elena</creatorcontrib><creatorcontrib>VIO, Luciano</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZAMPIERI, Daniele</au><au>GRAZIAMAMOLO, Maria</au><au>LAURINI, Erik</au><au>SCIALINO, Giuditta</au><au>BANFI, Elena</au><au>VIO, Luciano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2008-04-15</date><risdate>2008</risdate><volume>16</volume><issue>8</issue><spage>4516</spage><epage>4522</epage><pages>4516-4522</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>18321714</pmid><doi>10.1016/j.bmc.2008.02.055</doi><tpages>7</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0968-0896
ispartof	Bioorganic & medicinal chemistry, 2008-04, Vol.16 (8), p.4516-4522
issn	0968-0896 1464-3391
language	eng
recordid	cdi_proquest_miscellaneous_69127576
source	ScienceDirect Freedom Collection
subjects	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Candida albicans - drug effects Hydrogen - chemistry Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Pyrazoles - chemistry Structure-Activity Relationship
title	Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T11%3A28%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antifungal%20and%20antimycobacterial%20activity%20of%201-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole%20derivatives&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=ZAMPIERI,%20Daniele&rft.date=2008-04-15&rft.volume=16&rft.issue=8&rft.spage=4516&rft.epage=4522&rft.pages=4516-4522&rft.issn=0968-0896&rft.eissn=1464-3391&rft_id=info:doi/10.1016/j.bmc.2008.02.055&rft_dat=%3Cproquest_cross%3E69127576%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c329t-978e6631746129d133e1325d99996318746d1a0fcc94eb2b547b582bfc7b36c13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69127576&rft_id=info:pmid/18321714&rfr_iscdi=true