Post-menopausal women and osteoporosis: available choices for maintenance of skeletal health

Objective: To briefly summarize the therapeutic choices for osteoporosis prevention which are currently available to post-menopausal women. Methods: Results of randomized clinical trials and epidemiological studies in post-menopausal women, and pre-clinical studies in ovariectomized rats were summar...

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Bibliographic Details
Published in:Maturitas 1998-11, Vol.30 (3), p.241-245
Main Authors: Termine, John D, Wong, Mayme
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Epidemiologic Studies
Estrogen Antagonists - therapeutic use
Female
Hormone Replacement Therapy
Humans
Osteoporosis
Osteoporosis, Postmenopausal - prevention & control
Post-menopausal
Randomized Controlled Trials as Topic
Rats
Selective estrogen receptor modulators
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Summary:Objective: To briefly summarize the therapeutic choices for osteoporosis prevention which are currently available to post-menopausal women. Methods: Results of randomized clinical trials and epidemiological studies in post-menopausal women, and pre-clinical studies in ovariectomized rats were summarized. Results: Estrogen combined with progestogen in hormone replacement therapy (HRT) is effective in relieving perimenopausal symptoms and maintaining bone mineral density. However, the increased breast cancer risk associated with long-term HRT use makes it a less desirable option for many women. Selective estrogen receptor modulators (SERMs), such as raloxifene, are also effective in maintaining bone density, without stimulating the breast or uterus. However, SERMs do not relieve perimenopausal hot flashes. Conclusion: HRT is effective for acute relief of perimenopausal symptoms, but for women who are unwilling or unable to take HRT long-term, SERMs such as raloxifene are a useful therapy for the prevention of osteoporosis.
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(98)00092-9